منابع مشابه
Pulmonary Drug Delivery
Growing attention has been given to the potential of a pulmonary route as an noninvasive administration for systemic delivery of therapeutic agents (mainly peptides and proteins) due to the fact that the lungs could provide a large absorptive surface area (up to 100 m ) but extremely thin (0.1 μm – 0.2 μm) absorptive mucosal membrane and good blood supply. However, recent advances show great pr...
متن کاملPulmonary Drug Delivery System
Pulmonary drug delivery is primarily use to treat conditions of the airways, delivering locally acting drugs directly to their site of action. These routes of drug delivery may give the advantages like small amount of drug, less adverse reaction and rapid onset of action. The human respiratory system is complicated organ system these system consist of two reagions conducting airways and respira...
متن کاملBiophysical interaction between corticosteroids and natural surfactant preparation: implications for pulmonary drug delivery using surfactant a a carrier.
Intratracheal administration of corticosteroids using a natural pulmonary surfactant as a delivery vehicle has recently received significant attention in hopes of treating premature newborns with or at high risk for chronic lung disease. As a new practice, both the surfactant preparation used as the carrier and the corticosteroid delivered as the anti-inflammatory agent, and their mixing ratios...
متن کاملSurfactant-Free O/W-Emulsion as Drug Delivery System
Abstract—Most of the drugs used for pharmaceutical purposes are poorly water-soluble drugs. About 40% of all newly discovered drugs are lipophilic and the numbers of lipophilic drugs seem to increase more and more. Drug delivery systems such as nanoparticles, micelles or liposomes are applied to improve their solubility and thus their bioavailability. Besides various techniques of solubilizatio...
متن کاملBetter Neonatal Outcomes: Oxygen, Surfactant and Drug Delivery
clinical point of view for about 40 years [1] . Indeed, the first randomized trial of surfactant replacement for severe respiratory distress syndrome (RDS) using natural surfactant from human amniotic fluid was reported by Hallman et al. [2] in 1985. Surfactant replacement and concomitant treatment practices have virtually eliminated fatal respiratory failure soon after preterm birth. In additi...
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ژورنال
عنوان ژورنال: Pediatrics & Neonatology
سال: 2015
ISSN: 1875-9572
DOI: 10.1016/j.pedneo.2014.11.001